99 Results for "

Codonopsis javanica (Blume) Hook. f.

" in MedChemExpress (MCE) Product Catalog:
Products (99)

99 Results for "Codonopsis javanica (Blume) Hook. f." in MCE Product Catalog:

6
Corynoxeine
Corynoxeine
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6 Publications Verification
Cat. No.: HY-N0590
CAS No.: 630-94-4
Category:  

Cardiovascular Disease Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Disease Research Fields Indole Alkaloids

Target:  

ERK

Corynoxeine, isolated from the hook of Uncaria rhynchophylla, is a potent ERK1/ERK2 inhibitor of key PDGF-BB-induced vascular smooth muscle cells (VSMCs) proliferation.
4
Lobetyolin
Lobetyolin
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4 Cited Publications
Cat. No.: HY-N0327
CAS No.: 129277-38-9
Category:  

Natural Products Campanulaceae Metabolic Disease Codonopsis pilosula (Franch.) Nannf. Plants Disease Research Fields

Target:  

Apoptosis Xanthine Oxidase

Lobetyolin, a bioactive compound, is derived from Codonopsis pilosula. Lobetyolin has anti-inflammatory, anti-oxidative and xanthine oxidase inhibiting activities. Lobetyolin also induces the apoptosis via the inhibition of ASCT2-mediated glutamine metabolism . Lobetyolin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
3
Triptonide
Triptonide
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3 Cited Publications
Cat. No.: HY-32736
CAS No.: 38647-11-9
Synonyms: NSC 165677; PG 492
Category:  

Terpenoids Celastraceae Diterpenoids Plants Tripterygium wilfordii Hook. f. Disease Research Fields Inflammation/Immunology

Target:  

Wnt β-catenin Apoptosis Autophagy

Triptonide (NSC 165677) is a natural product identified in Tripterygium wilfordii Hook F.. Triptonide is a Wnt signaling inhibitor with an IC50 of appropriately 0.3 nM. Triptonide has immunosuppression, anti-inflammatory, anti-fertility, neuroprotective and anti-lymphoma effects .
3
Corynoxine
Corynoxine
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3 Cited Publications
Cat. No.: HY-N0901
CAS No.: 6877-32-3
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Indole Alkaloids

Target:  

Autophagy

Corynoxine, a tetracyclic oxindole alkaloid, is isolated from the hooks of Uncaria rhynchophylla. Corynoxine is a natural autophagy enhancer that promotes the clearance of alpha-synuclein via Akt/mTOR pathway .
2
Bruceantin
Bruceantin
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2 Cited Publications
Cat. No.: HY-N0840
CAS No.: 41451-75-6
Synonyms: (-)-Bruceantin; NCI165563; NSC165563
Category:  

Simaroubaceae Brucea antidysenterica J.F.Mill. Terpenoids Diterpenoids Plants Disease Research Fields Cancer Brucea javanica (L.) Merr.

Target:  

c-Myc Caspase Mitochondrial Metabolism Apoptosis Parasite

Bruceantin ((-)-Bruceantin) is a quassinoid found in B. javanica. Bruceantin activates caspase signaling pathway, causes the mitochondrial dysfunction, inhibits cell proliferation, induces cell differentiation and apoptosis. Bruceantin exhibits anti-leukemia and antiprotozoal activities .
2
3,7,4'-Trihydroxyflavone
3,7,4'-Trihydroxyflavone
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2 Cited Publications
Cat. No.: HY-111806
CAS No.: 2034-65-3
Purity:  99.44%
Synonyms: 5-Deoxykampferol; Resokaempferol
Category:  

Flavonols Rhus chinensis Mill. Plants Simaroubaceae Flavonoids Other Diseases Phenols Polyphenols Disease Research Fields Anacardiaceae Brucea javanica (L.) Merr.

Target:  

Reactive Oxygen Species (ROS) Leukotriene Receptor DNA/RNA Synthesis

3,7,4'-Trihydroxyflavone (5-Deoxykampferol) is a flavonoid compound that can be isolated from the stems of Rhus javanica var. roxburghiana. 3,7,4'-Trihydroxyflavone has the effect of cleaving DNA in the presence of copper ions. 3,7,4'-Trihydroxyflavone also has anti-inflammatory and antioxidant activities and can scavenge various reactive oxygen species (ROS) and reactive nitrogen species (RNS) .
1
Geissoschizine methyl ether
Geissoschizine methyl ether
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1 Cited Publications
Cat. No.: HY-N2411
CAS No.: 60314-89-8
Category:  

Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Rubiaceae Plants Indole Alkaloids

Target:  

5-HT Receptor

Geissoschizine methyl ether is an orally active, blood-brain barrier permeable alkaloid, and a partial agonist of the 5-HT1A receptor. It can be isolated from Uncaria hook. Geissoschizine methyl ether potently inhibits the binding of [ 3H]8-OH-DPAT to the 5-HT1A receptor in a concentration-dependent manner, with an IC50 of 0.904 μM. It ameliorates isolation-induced increased aggression and reduced sociability in mice. Geissoschizine methyl ether promotes oligodendrocyte differentiation and remyelination in the medial prefrontal cortex of adult mice .
1
Isorhamnetin 3-O-galactoside
Isorhamnetin 3-O-galactoside
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1 Cited Publications
Cat. No.: HY-N2082
CAS No.: 6743-92-6
Synonyms: Cacticin
Category:  

Cardiovascular Disease Flavonols Flavonoids Typhaceae Typha angustifolia L. Phenols Polyphenols Plants Disease Research Fields

Target:  

Thrombin COX ERK JNK Factor Xa

Isorhamnetin 3-O-galactoside (Cacticin) is a flavonoid glycoside that can be isolated from Oenanthe javanica, with antithrombotic and profibrinolytic activities. Isorhamnetin 3-O-galactoside inhibits the activities of thrombin and factor Xa (FXa) and reduces thrombin-catalyzed fibrin polymerization maximum rate. Isorhamnetin 3-O-galactoside suppresses TNF-α-induced PAI-1 secretion, decreases the PAI-1/tissue-type plasminogen activator (t-PA) ratio, and inhibits FXa production and FVa/FXa-mediated thrombin generation. Isorhamnetin 3-O-galactoside exerts protective effects against Carbon tetrachloride (CCl4) (HY-Y0298)-induced hepatic injury in mice. Isorhamnetin 3-O-galactoside can be used for the study of liver injury-related diseases and thrombotic vascular diseases .
Ilexoside D
Ilexoside D
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Cat. No.: HY-N5037
CAS No.: 109008-27-7
Category:  

Cardiovascular Disease Aquifoliaceae Triterpenes Terpenoids Plants Disease Research Fields Tabernaemontana elegans Stapf

Target:  

Others

Ilexoside D is isolated from the roots of Ilex pubescens Hook. et Arn. Ilexoside D has the anti-tissue factor activity as well as the antithrombotic activity .
Parishin C
Parishin C
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Cat. No.: HY-N2125
CAS No.: 174972-80-6
Category:  

Gastrodia elata Bl. Orchidaceae Phenols Plants

Target:  

5-HT Receptor iGluR Caspase Interleukin Related TNF Receptor SOD NF-κB

Parishin C is a brain-penetrant major bioactive component found in Gastrodia elata Blume. Parishin C is a 5-HT1A receptor agonist with an EC50 of 34 nM. Parishin C has antipsychotic and neuroprotective effects. Parishin C protects against Aβ-induced long-term potentiation damage and NMDA receptor current impairment. Parishin C reduces oxidative stress, pro-inflammatory cytokine levels, caspase activity, brain water content, and cerebral infarct volume; increases antioxidant enzyme activity and BDNF levels; improves nerve function and histopathological brain damage. Parishin C attenuates phencyclidine-induced immobility time increases, sociability deficits, and visual recognition memory impairment. Parishin C can be used for the research of ischemic stroke, Alzheimer's disease, and schizophrenia-like psychosis .
Tangshenoside I
Tangshenoside I
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Cat. No.: HY-N9317
CAS No.: 117278-74-7
Category:  

Ketones, Aldehydes, Acids Campanulaceae Metabolic Disease Codonopsis lanceolata (Sieb. et Zucc.) Trautv. Plants Disease Research Fields

Target:  

Glycosidase

Tangshenoside I, isolated from the roots of Codonopsis lanceolata, exhibits weak α-glucosidase inhibitory activities in vitro with an IC50 of 1.4 mM .
Wilforlide A
Wilforlide A
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Cat. No.: HY-N0476
CAS No.: 84104-71-2
Synonyms: Regelide; Abruslactone A
Category:  

Triterpenes Terpenoids Celastraceae Plants Tripterygium wilfordii Hook. f. Disease Research Fields Inflammation/Immunology

Target:  

Others

Wilforlide A is a bioactive triterpene isolated from Tripterygium wilfordii Hook f. Wilforlide A has anti-inflammatory and immune suppressive effects .
25S-Inokosterone
25S-Inokosterone
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Cat. No.: HY-N4130
CAS No.: 19595-18-7
Category:  

Amaranthaceae Plants Cyathula capitata Moq. Disease Research Fields Inflammation/Immunology Steroids

Target:  

Others

25S-Inokosterone is a phytoecdysone in the roots of two same species of A. bidentata Blume and A. japonica Nakai, and two different species of C. capitata Moq and C. officinalis Kuan. 25S-Inokosterone has the potential for the LPS-induced acute kidney injury research .
Yadanziolide A
Yadanziolide A
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Cat. No.: HY-N4210
CAS No.: 95258-14-3
Category:  

Infection Simaroubaceae Terpenoids Diterpenoids Plants Disease Research Fields Brucea javanica (L.) Merr.

Target:  

TMV

Yadanziolide A, isolated from the cultivated dry seeds of Brucea javanica, has strong antiviral activities with IC50 of 5.5 μM against tobacco mosaic virus. Yadanziolide A shows significant antitumor effects .
PROTAC Chk1 degrader-1
PROTAC Chk1 degrader-1
0 Images
Cat. No.: HY-161108
CAS No.: 2597167-34-3
Target:  

PROTACs Checkpoint Kinase (Chk)

Research Areas:  

Cancer

PROTAC Chk1 degrader-1 is a Chk1-targeting PROTAC.PROTAC Chk1 degrader-1 recruits the Cereblon E3 ligase to induce ubiquitination and proteasomal degradation of Chk1.PROTAC Chk1 degrader-1 exhibits Chk1 degradation activity in malignant melanoma cells without showing a hook effect.PROTAC Chk1 degrader-1 can be used for the research of malignant melanoma .
Bruceantinol
Bruceantinol
0 Images
Cat. No.: HY-N8146
CAS No.: 53729-52-5
Category:  

Infection Triterpenes Simaroubaceae Brucea antidysenterica J.F.Mill. Terpenoids Plants Disease Research Fields Cancer Brucea javanica (L.) Merr.

Target:  

STAT Bcl-2 Family Ser/Thr Kinase Survivin c-Myc Apoptosis Necroptosis CDK

Bruceantinol is a quassinoid that can be isolated from Brucea javanica, inhibits pepper mottle virus (PepMoV) in pepper. Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol has potent anti-leukemic activity. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC50 = 2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of MCL-1, PTTG1, survivin and c-Myc. Bruceantinol binds with CDK2/4/6 to facilitate protein degradation through proteasome pathway. Bruceantinol can dose- and time-dependently reduces the cell growth, impede cell proliferation, disrupts the cell cycle, and induces necrosis in MCF-7 cells and apoptosis in MDA-MB-231 cells .
Bruceine E
Bruceine E
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Cat. No.: HY-N3015
CAS No.: 21586-90-3
Category:  

Simaroubaceae Terpenoids Metabolic Disease Diterpenoids Plants Disease Research Fields Brucea javanica (L.) Merr.

Target:  

Others

Bruceine E is a quassinoid from seeds of Brucea javanica (L.) Merr, exhibiting hypoglycemia effect . Bruceine E exhibits blood glucose lowering effect in both nondiabetic mice and Streptozotocin (STZ (HY-13753))-induced diabetic rats at lower dose .
Lobetyolinin
Lobetyolinin
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Cat. No.: HY-124031
CAS No.: 142451-48-7
Purity:  98.98%
Category:  

Cardiovascular Disease Natural Products other families Plants Disease Research Fields

Target:  

Drug Derivative

Lobetyolinin is a polyacetylene compound. Lobetyolinin can be extracted from the traditional Chinese medicine Codonopsis pilosula. Lobetyolinin has antiarrhythmic effects. Lobetyolinin can be used in liver cancer research .
(-)-Codonopsine
(-)-Codonopsine
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Cat. No.: HY-N11554
CAS No.: 26989-20-8
Category:  

Alkaloids Pyrrole Alkaloids Campanulaceae Codonopsis pilosula (Franch.) Nannf. Plants

Target:  

Bacterial

(-)-Codonopsine is an alkaloid with antibacterial activity. (-)-Codonopsine can be used in research related to Staphylococcus aureus and Escherichia coli infections .
Bruceine J
Bruceine J
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Cat. No.: HY-N10899
CAS No.: 948038-38-8
Category:  

Simaroubaceae Terpenoids Diterpenoids Plants Brucea javanica (L.) Merr.

Target:  

Parasite

Bruceine J, a quassinoid, is a nature product that could be isolated from fruits of Br. jaVanica. Bruceine J has anti-Babesial activity .
Assay Types